Macrodasines AeG, macroline indole alkaloids incorporating fused spirocyclic tetrahydrofuranetetrahydrofuran and tetrahydrofuranetetrahydropyran rings
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چکیده
The bark extract of the Malayan Alstonia angustifoliaWall provided the spirocyclic alkaloids macrodasines AeG. The structures of the new compounds were established by analysis of the spectroscopic data and in the case of macrodasines A and B confirmed by X-ray diffraction analysis. Macrodasines A, B, C, and G incorporate fused spirocyclic tetrahydrofuranetetrahydrofuran rings, while macrodasines D, E, and F incorporate fused tetrahydrofuranetetrahydropyran rings. Macrodasines B, C, and E were found to show moderate levels of activity in reversing multidrug-resistance in drug-resistant KB cells. 2011 Elsevier Ltd. All rights reserved.
منابع مشابه
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تاریخ انتشار 2011